New therapeutic approaches in the management of castration resistan prostate cancer

Ioannis Gkialas

Abstract


Building on decades of research, the past few years have yielded a near exponential increase in treatment modalities for patients with metastatic prostate cancer.  Individually, these improvements in overall survival may appear modest, however, nearly all of them have a distinct mechanism of action and the possibility of synergistic effects have yet to be established. The promise of a durable impact on the mortality from metastatic prostate cancer will likely stem from further elucidation of molecular pathways involved in prostate cancer, as well as defining the optimal sequence of treatment for patients with metastatic prostate cancer.

Η ανάπτυξη των νέων προσεγγίσεων στη διαχείριση του προχωρημένου μεταστατικού καρκίνου του προστάτη έχει σημειώσει μεγάλη πρόοδο τα τελευταία χρόνια.Οι βασικές θεραπείες στέρησης ανδρογόνων (ADT) έχουν τελειοποιηθεί και πολλοί νέοι παράγοντες έχουν εγκριθεί από το 2010 για τη θεραπεία τόσο του μεταστατικού όσο και του ευνουχοάντοχου καρκίνου του προστάτη (mCRPC). Η κατανόηση της θεωρίας αυτών των νέων παραγόντων και η εστιασμένη προσεγγισή τους σε πρακτικές κλινικές εφαρμογές είναι απαραίτητες για τη βελτίωση των θεραπευτικών αποτελεσμάτων. Καθώς η αντιμετώπιση αυτών των ασθενών με προχωρημένη νόσο γίνεται πλέον πολυδιάστατη και η χρήση αυτών των παραγόντων επεκτείνεται, σε ουρολόγους, ογκολόγους και ακτινοθεραπευτές θα πρέπει ολοι να γίνουν πιο εξοικειωμένοι με τις νέες θεραπευτικές επιλογές.

 


Keywords


prostate cancer; castration resistant; therapy;προστατικός καρκίνος ευνουχο άντοχος; θεραπεία

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References


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DOI: http://dx.doi.org/10.19264/hj.v27i3.85